Yearly Archives: 2014


In the blood, DNA changes anticipate future cancer

A common, pre-cancerous state can precede cancer by many years and is readily detectable by DNA sequencing, according to a new paper by Giulio Genovese and colleagues in the New England Journal of Medicine.

Genovese discovered somatic (acquired) mutations from their presence at unusual

allelic fractions – reflecting that they are present in some, but not all, of the cells in a person’s blood.

DNA replication varies among humans

A process as fundamental as replication of a genome varies from person – shaped by common, inherited genetic variation that can also affect risk of cancer. The work is described in a new paper by Amnon Koren and colleagues in Cell.

Koren found hundreds of places in the human genome that some humans replicate earlier than others do.

Found at last: the human genome’s missing pieces

The mystery had tantalized geneticists for 15 years: scores of genes and millions of bases of human DNA sequence had no home on maps of the human genome. Where in the human genome were they hiding? The mystery is solved – with mathematics – in a paper by Giulio Genovese and colleagues in Nature Genetics.

Researchers had long wondered where the human genome’s “missing pieces” were hiding – and what had hidden them from view.