A common, pre-cancerous state can precede cancer by many years and is readily detectable by DNA sequencing, according to a new paper by Giulio Genovese and colleagues in the New England Journal of Medicine.
A process as fundamental as replication of a genome varies from person – shaped by common, inherited genetic variation that can also affect risk of cancer. The work is described in a new paper by Amnon Koren and colleagues in Cell.
Macosko will continue his work to develop “Drop-Seq”, a technology for profiling gene expression in thousands of single cells at once.
The mystery had tantalized geneticists for 15 years: scores of genes and millions of bases of human DNA sequence had no home on maps of the human genome. Where in the human genome were they hiding? The mystery is solved – with mathematics – in a paper by Giulio Genovese and colleagues in Nature Genetics.
The citation for the award acknowledged Handsaker’s international leadership in the analysis of human genome structural variation.