Arpiar Saunders receives a Helen Hay Whitney Fellowship.

Arpy Saunders has received a three-year post-doctoral fellowship from the Helen Hay Whitney Foundation (HHW), marking another step on his scientific journey that started in a cabin in the New Hampshire woods. Having grown up there, it is no surprise that, before coming to our lab, he studied outdoorsy science such as bird behavior in […]


The Neuroethics of Biomarkers

Matt Baum publishes his book, ‘The Neuroethics of Biomarkers’.

Matt Baum (a student in the lab) has written a book, published by Oxford University Press and available through Amazon, on the challenges and controversies involved in using disease biomarkers to evaluate patients, judge criminals, and make moral decisions. The book shines in its plethora of practical, thought-provoking examples and hypotheticals. In an example that […]

Cells and alleles in droplets

Two new papers from the McCarroll lab describe ways of using nanoliter droplets to answer questions in genetics and biology.  Droplets provide a way of scaling molecular biological reactions across tens of thousands of tiny reaction compartments.   In Drop-phase, Jack Regan, Nolan Kamitaki and colleagues describe a way to quickly determine the chromosomal phase of […]

Nanoliter-sized droplets make it possible to perform molecular-biological reactions in thousands of compartments simultaneously.

Genovese discovered somatic (acquired) mutations from their presence at unusual

allelic fractions – reflecting that they are present in some, but not all, of the cells in a person’s blood.

In the blood, DNA changes anticipate future cancer

A common, pre-cancerous state can precede cancer by many years and is readily detectable by DNA sequencing, according to a new paper by Giulio Genovese and colleagues in the New England Journal of Medicine.

DNA replication varies among humans

A process as fundamental as replication of a genome varies from person – shaped by common, inherited genetic variation that can also affect risk of cancer. The work is described in a new paper by Amnon Koren and colleagues in Cell.

Koren found hundreds of places in the human genome that some humans replicate earlier than others do.

Found at last: the human genome’s missing pieces

The mystery had tantalized geneticists for 15 years: scores of genes and millions of bases of human DNA sequence had no home on maps of the human genome. Where in the human genome were they hiding? The mystery is solved – with mathematics – in a paper by Giulio Genovese and colleagues in Nature Genetics.

Researchers had long wondered where the human genome’s “missing pieces” were hiding – and what had hidden them from view.